PySide is a Python binding of the cross-platform GUI toolkit Qt. Applications built with PySide will run on any platform supported by Qt & Python including Windows, OS X, Linux, iOS and Android.
PySide is the official binding for Qt on Python and is now developed by The Qt Company itself.
For a complete guide to desktop application development with Python & PySide, see the PySide tutorial and PySide book Create Simple GUI Applications with Python & Qt.
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